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Hydrocortisone 21-hemisuccinate
CAS No. 2203-97-6
Hydrocortisone 21-hemisuccinate( Hydrocortisone hemisuccinate anhydrous )
Catalog No. M18250 CAS No. 2203-97-6
Hydrocortisone 21-hemisuccinate is a corticosteroid used as an analytical and chromatography reagent.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 25MG | 39 | In Stock |
|
| 50MG | 55 | In Stock |
|
| 100MG | 71 | In Stock |
|
| 500MG | 174 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameHydrocortisone 21-hemisuccinate
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NoteResearch use only, not for human use.
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Brief DescriptionHydrocortisone 21-hemisuccinate is a corticosteroid used as an analytical and chromatography reagent.
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DescriptionHydrocortisone hemisuccinate anhydrous is an anti-inflammatory agent.(In Vitro):Hydrocortisone hemisuccinate inhibits IL-6 and IL-3 bioactivity, with IC50s of 6.7 and 21.4 μM, respectively, and shows no cytotoxic effects on IL-6-independent MH60 cells.Hydrocortisone hemisuccinate (0.12-60 μM; 72 h) inhibits phytohemagglutinin (PHA) response in peripheral lymphocytes (PBL) and T-lymphocytes cultures.(In Vivo):Hydrocortisone hemisuccinate (30 mg/kg; p.o. twice daily for 5 d) reduces the weight loss and increases the food intake in mice.
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In VitroHydrocortisone hemisuccinate inhibits IL-6 and IL-3 bioactivity, with IC50s of 6.7 and 21.4 μM, respectively, and shows no cytotoxic effects on IL-6-independent MH60 cells.Hydrocortisone hemisuccinate (0.12-60 μM; 72 h) inhibits phytohemagglutinin (PHA) response in peripheral lymphocytes (PBL) and T-lymphocytes cultures.
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In VivoHydrocortisone hemisuccinate (30 mg/kg; p.o. twice daily for 5 d) reduces the weight loss and increases the food intake in mice. Animal Model:Male Sprague-Dawley rats (200-220 g, 10-11 weeks) are induced colitis Dosage:30 mg/kg Administration:P.o. twice daily for 5 days Result:Significantly decreased the disease activity index (DAI) scores and myeloperoxidase (MPO) activity compared to the 2, 4, 6-trinitrobenzenesulfonic acid (TNBS) group.Increased the body weight.
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SynonymsHydrocortisone hemisuccinate anhydrous
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PathwayOthers
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TargetOther Targets
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RecptorOthers
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Research Area——
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Indication——
Chemical Information
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CAS Number2203-97-6
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Formula Weight462.53
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Molecular FormulaC25H34O8
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 250 mg/mL (540.51 mM)
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SMILES[H][C@@]12CC[C@](O)(C(=O)COC(=O)CCC(O)=O)[C@@]1(C)C[C@H](O)[C@@]1([H])[C@@]2([H])CCC2=CC(=O)CC[C@]12C
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Chemical Name4-(2-((8S,9R,10R,11S,13S,14S,17R)-11,17-dihydroxy-10,13-dimethyl-3-oxo-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl)-2-oxoethoxy)-4-oxobutanoic acid
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
molnova catalog
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